OtherColorectal cancer

Colorectal cancer statistics, 2026

CA A Cancer J Clinicians · 2026Not stated in the abstract of the paper
Siegel RL, Wagle NS, Star J, Kratzer TB, Smith RA, Jemal A. CA A Cancer J Clinicians. 2026. 76:e70067
Study type
Other
Study name
Colorectal cancer statistics, 2026
Design
Epidemiological statistical report based on data from population-based cancer registries (incidence) and the US National Center for Health Statistics (mortality)
Sample size
Not stated in the abstract of the paper
Source
CA A Cancer J Clinicians · 2026

In plain words

This report shows that bowel (colorectal) cancer has become less common in people over 65, but is increasing in younger adults, especially under 50 and also aged 50 to 64. Deaths are also rising in people under 65. Early diagnosis through screening and paying attention to symptoms, even at younger ages, can help. Younger patients should also talk to their doctor about protecting fertility and sexual health.

Key results

Decrease of 0.9% per year
Annual change in overall colorectal cancer incidence (2013 to 2022)
Driven by a decrease of 2.5% per year in adults aged 65 years and older
Increase of 3% per year
Annual change in incidence at ages 20 to 49 years
Mainly tumours of the distal colon and rectum
Increase of 0.4% per year
Annual change in incidence at ages 50 to 64 years
Mainly tumours of the distal colon and rectum
Increase of 1% per year
Rectal cancer incidence (2018 to 2022)
After decades of decline; now 32% of all colorectal cancer cases versus 27% in the mid-2000s
1.1% to 1.3% per year (2013 to 2022)
Increase in incidence at ages 50 to 64 years by stage
Confined to diagnosis at regional and distant stage
Increase of 1% per year
Mortality at ages 50 to 64 years since 2019
Steepest increase (2.3% per year) in White people
Increase of 1% per year
Mortality under 50 years since 2004
Decrease of 2.3% per year
Mortality at 65 years and older since 2012

Study population

The US population; incidence based on population-based cancer registries and mortality based on data from the National Center for Health Statistics. Trends are reported for different age groups (20 to 49 years, 50 to 64 years, 65 years and older).

Endpoints

Trends in colorectal cancer incidence (2013 to 2022) and mortality by age group, tumour site (distal colon and rectum) and stage at diagnosis.

Safety and side effects

This study is a statistical report with no treatment intervention, so treatment adverse events were not assessed.

Clinical significance and place in guidelines

Based on the abstract, the burden of colorectal cancer has shifted towards younger and middle-aged adults, and rectal cancer makes up a larger share of cases. The authors emphasise earlier diagnosis through screening, educating clinicians and the public about symptoms, and attention to the needs of younger patients (including fertility preservation and sexual health). This paper is a statistical report and the abstract gives no new clinical recommendations or screening guidance; the status of screening guidelines should be checked separately. The data relate to the United States, and their generalisation to other countries cannot be inferred from the abstract.

Limitations

Based on the abstract, this report is descriptive and based on population registry data and mortality statistics, and does not identify the cause of the rising incidence and mortality in younger adults; the authors call for urgent aetiological research. The data relate to the United States. Detailed limitations should be checked in the full text of the paper.

This summary was prepared by the editorial team from the published paper; the original paper is the final reference. Read the original abstract on PubMed.