Clinical guidelineBlood cancers (leukaemia, lymphoma and myeloma)Leukaemia

Diagnosis, prognostic factors, and assessment of ALL in adults: 2024 ELN recommendations from a European expert panel

Blood · 2024
Gökbuget N, Boissel N, Chiaretti S, Dombret H, Doubek M, Fielding A, et al. Blood. 2024. 143:1891-1902
Study type
Clinical guideline
Study name
ELN 2024 (ALL)
Design
Consensus recommendations of the European working group for adult ALL within the European LeukemiaNet (ELN)
Source
Blood · 2024

In plain words

This European guideline explains how ALL in adults should be diagnosed, which genetic tests are needed and how the risk of the disease is assessed. The most important predictor is the response to treatment measured by a very sensitive test for remaining disease (MRD).

Study population

Adults with acute lymphoblastic leukaemia (ALL).

Clinical significance and place in guidelines

Sets European standards for the diagnosis and risk classification of adult ALL and recommends MRD testing in all patients for risk stratification; treatment recommendations are given in the companion paper ("Management of ALL in adults: 2024 ELN recommendations").

Limitations

Based on the consensus of European experts and should be complemented by the experience of national groups.

This summary was prepared by the editorial team from the published paper; the original paper is the final reference. Read the original abstract on PubMed.