Latest Cancer TreatmentsDr. Mohammadreza Dabiri
Dr. Mohammadreza Dabiriفارسی
Treatment regimen

The Stupp regimen: temozolomide with radiotherapy in glioblastoma

Daily temozolomide during radiotherapy, then 6 adjuvant cycles

Updated: 28 October 20261 min read2 references

Summary for doctors

  • Glioblastoma after surgery [1].
  • MGMT-methylated tumours respond better.
  • Pneumocystis prophylaxis during the concomitant phase [1].

Dose and schedule

Stupp

Newly diagnosed glioblastoma

Newly diagnosed glioblastoma

DrugDoseRouteSchedule
Concomitant phase
Temozolomide75 mg/m²OralDaily during radiotherapy (60 Gy in 30 fractions)
Adjuvant phase
Temozolomide150 mg/m² in cycle 1, then 200 if toleratedOral, fastingDays 1 to 5
Cycle length
Adjuvant phase every 28 days, starting 4 weeks after the end of radiotherapy
Duration
6 adjuvant cycles

As in Stupp and colleagues [1].

Dose source: [2].

Evidence: EORTC 26981-22981 / NCIC CE.3 (Stupp) (2005)

Doses follow the trial protocol, guideline or official drug label (source given in the notes of each regimen). Before prescribing, check blood counts, renal and hepatic function, drug interactions and the patient’s condition, and adjust the dose according to the drug label.

Premedication and supportive care

  • Co-trimoxazole pneumocystis prophylaxis during the concomitant phase (and with prolonged lymphopenia).
  • Antiemetics: a 5-HT3 antagonist before each dose in the adjuvant phase.

Monitoring and dose adjustment

  • Weekly blood counts in the concomitant phase and on day 21 of each adjuvant cycle; increase to 200 only if the ANC and platelets were adequate.
  • Prolonged thrombocytopenia is common.

Main evidence

Show detailsHide

Adding temozolomide to radiotherapy increased median survival from 12.1 to 14.6 months and 2-year survival from 10.4% to 26.5% [1].

Related cancer types

Brain tumours

Physician tools and lessons

Management of brain metastases

References

2 references
Show all references, 1 with a study cardClose the reference list

Numbers in the text, such as [1], refer to these sources. Sources with a “Study card” button are summarised in the site’s evidence library.

  1. 1
    Radiotherapy plus concomitant and adjuvant temozolomide for glioblastomaStupp R, Mason WP, van den Bent MJ, et al · N Engl J Med · 2005;352:987-96
    Study cardDOIPubMed Back to text: 1 2 3 4
  2. 2
    TEMODAR (TEMOZOLOMIDE) — Prescribing InformationPhysicians Total Care, Inc · FDA label · 2026
    Source Back to text

This page is based on reputable scientific sources and was last updated on 28 October 2026. The content of this website is for educational and informational purposes only and does not replace consultation, diagnosis or treatment by a specialist physician. Consult your treating physician about any treatment decision.

Printed from the website; the full and up-to-date version: https://drdabiri.com/en/regimens/stupp-temozolomide/

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