Latest Cancer TreatmentsDr. Mohammadreza Dabiri
Dr. Mohammadreza Dabiriفارسی
Treatment regimen

Weekly cisplatin with radiotherapy (cervical cancer)

Concurrent chemoradiotherapy in locally advanced cervical cancer

Updated: 28 October 20261 min read1 reference

Summary for doctors

  • Stage IB3 to IVA cervical cancer [1].
  • 5 to 6 weeks with external beam radiotherapy, then brachytherapy.
  • Keep the total treatment time under 8 weeks.

Dose and schedule

Weekly cisplatin

Locally advanced cervical cancer, with radiotherapyCycle length: Weekly

Locally advanced cervical cancer, with radiotherapy

DrugDoseRouteSchedule
Cisplatin40 mg/m²IVWeekly during radiotherapy
Cycle length
Weekly
Duration
5 to 6 doses

As in GOG 120 [1]. Many centres cap each dose at 70 mg.

Evidence: GOG (1999)

Doses follow the trial protocol, guideline or official drug label (source given in the notes of each regimen). Before prescribing, check blood counts, renal and hepatic function, drug interactions and the patient’s condition, and adjust the dose according to the drug label.

Premedication and supportive care

  • Hydration and magnesium; antiemetics: 5-HT3 and dexamethasone (and NK1 if needed).

Monitoring and dose adjustment

  • Weekly blood counts and creatinine; omit the dose with an ANC below 1000 to 1500 or a creatinine clearance below 50, but do not interrupt radiotherapy.

Main evidence

Show detailsHide

In GOG 120, cisplatin-based regimens with radiotherapy lowered the risk of death by about 40% compared with hydroxyurea, and weekly cisplatin was the simplest and least toxic [1].

Related cancer types

Cervical cancer

Treatment regimens (physicians)

Carboplatin and paclitaxel in ovarian cancerPembrolizumab in cervical cancer: with chemoradiotherapy and in metastatic disease

Physician tools and lessons

Cancer during pregnancy: chemotherapy and decisions

References

1 reference
Show all references, 1 with a study cardClose the reference list

Numbers in the text, such as [1], refer to these sources. Sources with a “Study card” button are summarised in the site’s evidence library.

  1. 1
    Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancerRose PG, Bundy BN, Watkins EB, et al · N Engl J Med · 1999;340:1144-53
    Study cardDOIPubMed Back to text: 1 2 3

This page is based on reputable scientific sources and was last updated on 28 October 2026. The content of this website is for educational and informational purposes only and does not replace consultation, diagnosis or treatment by a specialist physician. Consult your treating physician about any treatment decision.

Printed from the website; the full and up-to-date version: https://drdabiri.com/en/regimens/weekly-cisplatin-chemoradiation/

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