OtherColorectal cancer

Colorectal cancer statistics, 2023

CA A Cancer J Clinicians · 2023Data from US population-based cancer registries and mortality statistics; sample size not stated in the abstract
Siegel RL, Wagle NS, Cercek A, Smith RA, Jemal A. CA A Cancer J Clinicians. 2023. 73:233-254
Study type
Other
Study name
ACS CRC Statistics 2023
Design
Epidemiological statistical report based on data from population-based cancer registries (triennial update of the American Cancer Society)
Sample size
Data from US population-based cancer registries and mortality statistics; sample size not stated in the abstract
Source
CA A Cancer J Clinicians · 2023

In plain words

This report shows that cancer of the colon and rectum is still one of the main causes of cancer death in the United States. Although overall death rates have fallen, the disease has become more common in younger people and is more often found at a later stage and in the last parts of the bowel (the left side and the rectum). Access to screening and good-quality treatment matters for every group.

Key results

About 153,020 diagnoses and 52,550 deaths
Estimated new cases and deaths in 2023 (total)
Estimate for the United States
19,550 cases and 3750 deaths
New cases and deaths in people under 50 (2023)
Decline of 3% to 4% per year in the 2000s vs 1% per year during 2011 to 2019
Overall incidence trend
Slowing of the decline in incidence
Increase of 1% to 2% per year since the mid-1990s
Incidence trend in people under 55
20% in 2019 vs 11% in 1995
Proportion of cases in people under 55
Regional stage: increase of about 2% to 3% per year; distant stage: increase of 0.5% to 3% per year
Incidence trend in people under 65 since about 2010
Reversal of the shift towards earlier-stage diagnosis that occurred from 1995 to 2005
60% in 2019 vs 52% in the mid-2000s and 57% in 1995
Proportion of new cases at advanced stage
1995: before widespread screening
31% in 2019 vs 27% in 1995
Proportion of rectal cancer
Shift towards left-sided tumours
Decline of 2% per year during 2011 to 2020 overall; increase of 0.5% to 3% per year in people under 50 and in Native Americans under 65
Mortality trend

Study population

The US population. Incidence data were drawn from population-based cancer registries and mortality data from the National Center for Health Statistics.

Endpoints

Trends in colorectal cancer (CRC) incidence and mortality, estimated numbers of cases and deaths for 2023, and distribution by age, stage and tumour location. Details of the methodology are given in the full text of the paper.

Safety and side effects

In keeping with the nature of the study (a statistical report), a safety and treatment adverse-event section does not apply.

Clinical significance and place in guidelines

This report is epidemiological and offers no new treatment or clinical recommendation. According to the abstract, the rising incidence in younger people and the increase in diagnosis at advanced stages underline the importance of access to high-quality screening and appropriate treatment, especially in underserved groups such as Native Americans. The data relate to the United States, and any change in screening recommendations should be checked against current authoritative clinical guidelines.

Limitations

The abstract does not mention limitations. The data relate to the United States and generalisation to other countries should be made with caution. The cause of the rising incidence in younger generations is still unclear. Details of the methodology are given in the full text of the paper.

This summary was prepared by the editorial team from the published paper; the original paper is the final reference. Read the original abstract on PubMed.