Clinical guideline

Exercise, Diet, and Weight Management During Cancer Treatment: ASCO Guideline

JCO · 202252 systematic reviews (42 on exercise, 9 on diet and 1 on weight management) and 23 additional randomised controlled trials
Ligibel JA, Bohlke K, May AM, Clinton SK, Demark-Wahnefried W, Gilchrist SC, et al. JCO. 2022. 40:2491-2507
Study type
Clinical guideline
Study name
ASCO Exercise, Diet, and Weight Management 2022
Design
Clinical practice guideline based on a systematic review of studies (systematic reviews and randomised controlled trials) and review by an ASCO expert panel
Sample size
52 systematic reviews (42 on exercise, 9 on diet and 1 on weight management) and 23 additional randomised controlled trials
Source
JCO · 2022

In plain words

Regular exercise, including aerobic exercise (such as walking) and resistance exercise, during cancer treatment can improve fitness and strength and reduce tiredness. For patients due to have surgery for lung cancer, exercise before the operation may shorten the hospital stay and reduce complications after surgery. A neutropenic diet (a very restricted diet meant to prevent infection) does not lower the risk of infection and is not recommended. Talk to your treating doctor before starting an exercise programme or changing your diet.

Key points

52 systematic reviews (42 exercise, 9 diet, 1 weight management) plus 23 randomised controlled trials
Volume of evidence
Search of PubMed and the Cochrane Library from January 2000 to May 2021
Improved cardiorespiratory fitness, strength, fatigue and other patient-reported outcomes
Exercise during cancer treatment
Shorter postoperative hospital stay and fewer complications
Preoperative exercise in lung cancer
Did not reduce the risk of infection during cancer treatment
Neutropenic diet

Key guideline recommendations

  1. Oncology providers should recommend regular aerobic and resistance exercise during active treatment with curative intent.

    Not stated in the abstract
  2. Oncology providers may recommend preoperative exercise for patients undergoing surgery for lung cancer.

    Not stated in the abstract
  3. Neutropenic diets are not recommended to prevent infection in patients with cancer during active treatment.

    Not stated in the abstract

Treatment arms and regimens

1Exercise (aerobic and resistance)

Aerobic and resistance exercise during cancer treatment. Dose details in the full text.

2Specific diets and foods

Specific diets and foods, including neutropenic diets. Dose details in the full text.

3Intentional weight loss and prevention of weight gain

Interventions for intentional weight loss and avoidance of weight gain during treatment. Dose details in the full text.

Source of the regimen details: Abstract of the paper; dose details in the full text

Doses are given for the information of specialists, as in this study’s protocol, and are not a prescription. Every drug must be prescribed by the treating physician for the individual patient.

Study population

Adults receiving active cancer treatment. The most common cancer types in the studies reviewed were breast, prostate, lung and colorectal cancer.

Endpoints

Effect of the interventions on quality of life, treatment toxicity and cancer control.

Safety and side effects

No quantitative adverse event data are reported in the abstract.

Clinical significance and place in guidelines

According to this guideline, the care team should recommend regular aerobic and resistance exercise to patients receiving active treatment with curative intent, and may recommend preoperative exercise for patients undergoing surgery for lung cancer. A neutropenic diet is not recommended for preventing infection. Evidence for other dietary and weight-loss interventions during treatment is very limited and more research is needed. The current status of the guideline and the level of evidence of each recommendation should be checked in the full text.

Limitations

Evidence on other dietary and weight-loss interventions during cancer treatment was very limited, and there is a critical need for more research, especially on diet and weight loss. The most common cancer types in the studies were breast, prostate, lung and colorectal.

This summary was prepared by the editorial team from the published paper; the original paper is the final reference. Read the original abstract on PubMed.