The Global Landscape of Esophageal Squamous Cell Carcinoma and Esophageal Adenocarcinoma Incidence and Mortality in 2020 and Projections to 2040: New Estimates From GLOBOCAN 2020
- Study type
- Other
- Study name
- GLOBOCAN 2020
- Design
- Descriptive epidemiological study based on GLOBOCAN 2020 data, with projections of the disease burden to 2040 based on global population estimates
- Sample size
- Data from 185 countries
- Source
- Gastroenterology · 2022
In plain words
This research shows that in 2020 oesophageal cancer affected about 604,000 people worldwide and caused about 544,000 deaths. Most cases were of the squamous-cell type, and the disease was much more common in men than in women. Rates of the disease differ greatly between regions of the world. Prevention and, in high-risk groups, screening and early diagnosis can help reduce the burden of this disease.
Key results
Study population
Estimates of new cases and deaths from oesophageal cancer in 185 countries were extracted from the GLOBOCAN 2020 database. Analyses were done by sex, histological subtype (adenocarcinoma [AC] and squamous-cell carcinoma [SCC]), country and Human Development Index level.
Endpoints
Main measures: estimated numbers of new cases and deaths and age-standardised incidence and mortality rates of oesophageal cancer in 2020 (by sex, histological subtype, country and Human Development Index level), and the projected incidence and mortality burden in 2040.
Safety and side effects
This is not an interventional study, and no treatment adverse events are reported.
Clinical significance and place in guidelines
This study is an epidemiological estimate and does not recommend or change any specific treatment. According to the abstract, these data provide a basis for prioritising health policies and oesophageal cancer control programmes and emphasise the role of primary prevention as well as screening and early diagnosis in high-risk populations. Any clinical recommendation or the status of treatment guidelines should be checked separately.
Limitations
The 2040 projections assume that rates remain constant and are calculated solely from global population projections. Other limitations (such as the quality and completeness of cancer registry data in different countries) are not given in the abstract and should be checked in the full text.
This summary was prepared by the editorial team from the published paper; the original paper is the final reference. Read the original abstract on PubMed.