Gastric cancer
- Study type
- Review article
- Study name
- Lancet Gastric Cancer Seminar 2020
- Design
- Review article (Seminar)
- Sample size
- Not applicable (review article)
- Source
- The Lancet · 2020
In plain words
Stomach (gastric) cancer is one of the most common cancers in the world and an important cause of cancer death. Infection with the bacterium Helicobacter pylori, eating a lot of salt and too little fruit and vegetables raise its risk. If the disease is found early, it can sometimes be treated by removing it through an endoscope; in more advanced cases surgery and chemotherapy are used, and at an advanced stage chemotherapy and targeted therapies or immunotherapy are important. The right treatment should be decided by your doctor according to your situation.
Key results
Study population
This is a review article and did not enrol specific patients. Its subject is gastric cancer in adults, from early to advanced stages.
Endpoints
Not applicable; this is a review article and defines no primary or secondary endpoints.
Safety and side effects
The abstract does not address adverse effects of treatments. Safety details are given in the full text of the paper.
Clinical significance and place in guidelines
This review summarises the overall approach to treating gastric cancer: endoscopic resection for early disease, surgery with D2 lymphadenectomy and perioperative or adjuvant chemotherapy for non-early disease of stage 1B or higher, and successive lines of systemic therapy for advanced disease. The abstract does not comment on changes to clinical practice or on the status of specific approvals and guidelines; the status of current guidelines should be checked separately.
Limitations
This is a narrative review and presents no new primary data. The abstract does not describe the literature search method or study selection criteria. The generalisability and level of evidence of each recommendation should be checked in the full text.
This summary was prepared by the editorial team from the published paper; the original paper is the final reference. Read the original abstract on PubMed.