Epidemiology of Renal Cell Carcinoma: 2022 Update
- Study type
- Review article
- Design
- Narrative review based on a systematic search (Medline/PubMed and Scopus)
- Sample size
- Not stated in the abstract
- Source
- European Urology · 2022
In plain words
This article reviews the evidence on how often kidney cancer occurs around the world. Its most important preventable causes are smoking, obesity and high blood pressure. Stopping smoking, controlling weight and treating high blood pressure may be the best chance to lower the risk of kidney cancer.
Key results
Study population
This study is a literature review and enrolled no patients. Sources included meta-analyses, reviews and original studies on renal cell carcinoma, epidemiology and risk factors.
Endpoints
The aim was to compile and summarise global incidence and mortality of kidney cancer and its associated risk factors. Familial syndromes and known genetic alterations that are considered biological risk factors were also described.
Safety and side effects
According to the abstract, this study is a literature review and reports no safety or treatment toxicity data.
Clinical significance and place in guidelines
This review shows that kidney cancer incidence is rising while mortality has plateaued. It emphasises modification of changeable risk factors (smoking, obesity, hypertension) and attention to patients with CKD/ESKD and genetic predisposition. This is an epidemiological review and not a clinical guideline; its status in formal guidelines should be checked separately.
Limitations
This study is a narrative review, and its data come from published, mainly observational, studies. Details of limitations are not given in the abstract and should be checked in the full text of the paper.
This summary was prepared by the editorial team from the published paper; the original paper is the final reference. Read the original abstract on PubMed.