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Dr. Mohammadreza Dabiriفارسی
Clinical tool

Creatinine Clearance and eGFR Calculator

Cockcroft-Gault with actual, ideal or adjusted weight; race-free CKD-EPI 2021

Updated: 27 October 20261 min read3 references

Shows creatinine clearance (Cockcroft-Gault) and eGFR (CKD-EPI 2021, race-free) together.

Sex
Weight for the Cockcroft-Gault formulaAdjusted weight is used only when actual weight is more than 120% of ideal weight.

This calculator needs JavaScript; the formula and its interpretation are in the text of this page.

An aid for clinicians; it does not replace clinical judgement, local protocols or the drug label. Double-check every result before prescribing.

Formulas

  • Cockcroft-Gault: clearance (mL/min) = (140 − age) × weight ÷ (72 × creatinine), × 0.85 in women [1].
  • CKD-EPI 2021: a race-free equation giving eGFR in mL/min/1.73 m² [2]. For drug dosing the de-indexed value (× BSA ÷ 1.73) is more meaningful.

Which one for drug dosing?

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Most labels of older drugs (cisplatin, capecitabine, pemetrexed, carboplatin with the Calvert formula…) are based on Cockcroft-Gault, so use it to follow the label. eGFR was designed for staging kidney disease [2].

Weight: in obesity, Cockcroft-Gault with actual weight overestimates clearance; many centres use adjusted weight when actual weight exceeds 120% of ideal. This does not conflict with full cytotoxic dosing in obesity, which concerns BSA [3].

Examples of clearance thresholds in drug labels
DrugThresholdAction in label
CisplatinBelow 60Often switched to carboplatin in protocols
Capecitabine30–50 / below 3075% dose / contraindicated
PemetrexedBelow 45Do not use

mL/min by Cockcroft-Gault; always check the label and protocol of the drug.

Common questions

Creatinine is very low (e.g., 0.4); what should I do?

In thin, older or immobile patients, a low creatinine overestimates clearance. Many centres round creatinine below 0.7–0.8 up, especially for carboplatin; measured GFR is the most accurate option.

References

3 references
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Numbers in the text, such as [1], refer to these sources. Sources with a “Study card” button are summarised in the site’s evidence library.

  1. 1
    Prediction of creatinine clearance from serum creatinineCockcroft DW, Gault MH · Nephron · 1976;16:31-41
    DOIPubMed Back to text
  2. 2
    New Creatinine- and Cystatin C-Based Equations to Estimate GFR without RaceInker LA, Eneanya ND, Coresh J, et al · N Engl J Med · 2021;385:1737-1749
    DOIPubMed Back to text: 1 2
  3. 3
    Appropriate Systemic Therapy Dosing for Obese Adult Patients With Cancer: ASCO Guideline UpdateGriggs JJ, Bohlke K, Balaban EP, et al · J Clin Oncol · 2021;39:2037-2048
    DOIPubMed Back to text

This page is based on reputable scientific sources and was last updated on 27 October 2026. The content of this website is for educational and informational purposes only and does not replace consultation, diagnosis or treatment by a specialist physician. Consult your treating physician about any treatment decision.

Printed from the website; the full and up-to-date version: https://drdabiri.com/en/tools/creatinine-clearance-calculator/

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