Latest Cancer TreatmentsDr. Mohammadreza Dabiri
Dr. Mohammadreza Dabiriفارسی
Treatment regimen

BV-AVD in advanced Hodgkin lymphoma

Brentuximab vedotin instead of bleomycin; stage 3 and 4

Updated: 28 October 20261 min read2 references

Summary for doctors

  • Stage 3 and 4 Hodgkin lymphoma [1].
  • No bleomycin; primary G-CSF prophylaxis is needed.
  • Peripheral neuropathy is the main toxicity [1].

Dose and schedule

BV-AVD

Advanced Hodgkin lymphoma, first lineCycle length: Every 28 days

Advanced Hodgkin lymphoma, first line

DrugDoseRouteSchedule
Brentuximab vedotin1.2 mg/kgIVDays 1 and 15
Doxorubicin25 mg/m²IVDays 1 and 15
Vinblastine6 mg/m²IVDays 1 and 15
Dacarbazine375 mg/m²IVDays 1 and 15
Cycle length
Every 28 days
Duration
6 cycles

As in ECHELON-1 [1].

Dose source: [2].

Doses follow the trial protocol, guideline or official drug label (source given in the notes of each regimen). Before prescribing, check blood counts, renal and hepatic function, drug interactions and the patient’s condition, and adjust the dose according to the drug label.

Premedication and supportive care

  • Primary G-CSF prophylaxis (pegfilgrastim or filgrastim) from cycle 1.
  • Highly emetogenic antiemetics (dacarbazine).

Monitoring and dose adjustment

  • Grade 2 neuropathy: brentuximab to 0.9 mg/kg; grade 3: hold until improvement.
  • Pancreatitis and PML are rare but serious.

Main evidence

Show detailsHide

ECHELON-1: 2-year modified progression-free survival 82.1% vs 77.2% with ABVD; more neuropathy and febrile neutropenia, less pulmonary toxicity [1]. With longer follow-up, overall survival was also longer.

Related cancer types

Lymphoma

Treatment regimens (physicians)

R-CHOP regimen: dose, schedule and practical pointsPola-R-CHP in DLBCLABVD in Hodgkin lymphoma and AVD after a negative PETBR regimen (bendamustine and rituximab)

Physician tools and lessons

Cumulative Anthracycline Dose and Doxorubicin EquivalentsTumour Lysis Syndrome: Cairo-Bishop Criteria and PreventionKhorana Score (Cancer-Associated Thrombosis Risk)HCT-CI Comorbidity Index Before Stem Cell TransplantationIPI, R-IPI, NCCN-IPI and CNS-IPI Calculator for DLBCLFollicular Lymphoma International Prognostic Index (FLIPI) CalculatorInternational Prognostic Score (IPS) for Advanced Hodgkin LymphomaMantle Cell Lymphoma International Prognostic Index (MIPI) CalculatorIndications for haematopoietic stem cell transplantation, donor selection and conditioningGraft-versus-host disease (GVHD): prophylaxis, grading and treatment

References

2 references
Show all referencesClose the reference list

Numbers in the text, such as [1], refer to these sources. Sources with a “Study card” button are summarised in the site’s evidence library.

  1. 1
    Brentuximab Vedotin with Chemotherapy for Stage III or IV Hodgkin's LymphomaConnors JM, Jurczak W, Straus DJ, et al · N Engl J Med · 2018;378:331-344
    DOIPubMed Back to text: 1 2 3 4
  2. 2
    ADCETRIS (BRENTUXIMAB VEDOTIN) — Prescribing InformationSeagen Inc · FDA label · 2026
    Source Back to text

This page is based on reputable scientific sources and was last updated on 28 October 2026. The content of this website is for educational and informational purposes only and does not replace consultation, diagnosis or treatment by a specialist physician. Consult your treating physician about any treatment decision.

Printed from the website; the full and up-to-date version: https://drdabiri.com/en/regimens/bv-avd/

Related pages

27 October 2026 FOLFOX (mFOLFOX6): dose, schedule and side effects Dose and schedule of mFOLFOX6 (oxaliplatin 85, leucovorin 400, fluorouracil 400 bolus and 2400 as a 46-hour infusion), length of adjuvant treatment, premedication, neuropathy and dose adjustment. 27 October 2026 CAPOX (XELOX): dose, schedule and side effects Dose and schedule of CAPOX or XELOX (oxaliplatin 130 and capecitabine 1000 twice daily, days 1 to 14), length of adjuvant treatment, renal adjustment and side effects. 27 October 2026 FOLFIRI regimen: dose, schedule and side effects Dose and schedule of FOLFIRI (irinotecan 180, leucovorin 400, fluorouracil 400 bolus and 2400 as a 46-hour infusion), diarrhoea control, UGT1A1 and dose adjustment.