Equivalence table
| Drug | Equivalent dose (mg) | Biological half-life |
|---|---|---|
| Hydrocortisone | 20 | Short |
| Prednisone / prednisolone | 5 | Intermediate |
| Methylprednisolone | 4 | Intermediate |
| Dexamethasone | 0.75 | Long |
These equivalents measure anti-inflammatory effect; the salt- and water-retaining (mineralocorticoid) effect is higher with hydrocortisone and almost nil with dexamethasone [1].
Doses are usually given per kilogram (e.g., prednisone 1 mg/kg or methylprednisolone 1–2 mg/kg), tapered over at least 4–6 weeks, with Pneumocystis prophylaxis if 20 mg of prednisone or more is continued for 4 weeks or longer. Details in the immunotherapy toxicity lesson.
References
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Numbers in the text, such as [1], refer to these sources. Sources with a “Study card” button are summarised in the site’s evidence library.
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This page is based on reputable scientific sources and was last updated on 27 October 2026. The content of this website is for educational and informational purposes only and does not replace consultation, diagnosis or treatment by a specialist physician. Consult your treating physician about any treatment decision.
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