Studies and guidelines: Skin cancer: basal cell and squamous cell carcinoma

6 items with a structured summary · Skin cancer: basal cell and squamous cell carcinoma: the complete guide

Clinical guideline

European consensus-based interdisciplinary guideline for invasive cutaneous squamous cell carcinoma: Part 2. Treatment - update 2026

Eur J Cancer · 2026
Clinical trial · Phase 2

Pembrolizumab Monotherapy for Recurrent or Metastatic Cutaneous Squamous Cell Carcinoma: A Single-Arm Phase II Trial (KEYNOTE-629)

J Clin Oncol · 2020
34.3%Objective response, recurrent or metastatic cohort (interim analysis)
Clinical trial · Phase 3

A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention

N Engl J Med · 2015
23% lower with nicotinamideRate of new non-melanoma skin cancer at 12 months
Clinical trial · Phase 2

Efficacy and safety of vismodegib in advanced basal-cell carcinoma

N Engl J Med · 2012
30%Objective response, metastatic (independent review)
Clinical trial · Phase 2

Neoadjuvant Cemiplimab for Stage II to IV Cutaneous Squamous-Cell Carcinoma

N Engl J Med · 2022
51%Pathological complete response (independent review)
Clinical trial · Phase 2

Cemiplimab in locally advanced basal cell carcinoma after hedgehog inhibitor therapy: an open-label, multi-centre, single-arm, phase 2 trial

Lancet Oncol · 2021
31%Objective response, locally advanced (independent review)