Latest Cancer TreatmentsDr. Mohammadreza Dabiri
Dr. Mohammadreza Dabiriفارسی
Clinical tool

CLL-IPI Calculator (Chronic Lymphocytic Leukaemia Prognostic Index)

TP53, IGHV, beta-2 microglobulin, stage and age

Updated: 27 October 20261 min read2 references

International Prognostic Index for chronic lymphocytic leukaemia (CLL-IPI).

This calculator needs JavaScript; the formula and its interpretation are in the text of this page.

An aid for clinicians; it does not replace clinical judgement, local protocols or the drug label. Double-check every result before prescribing.

Use today

CLL-IPI was derived in the chemoimmunotherapy era [1]. Today its most important part is testing TP53 (17p deletion and mutation) and IGHV before any treatment, because they decide the treatment: with TP53 aberration or unmutated IGHV, chemoimmunotherapy (such as FCR) has no place and targeted therapy (a BTK inhibitor or venetoclax-obinutuzumab) is the choice. Starting treatment is still based on the iwCLL criteria, not the score [2].

Read more: best treatment for CLL.

Related cancer types

Leukaemia

Treatment regimens (physicians)

BR regimen (bendamustine and rituximab)7+3 regimen (AML induction) and high-dose cytarabineAzacitidine with venetoclax in AMLTretinoin (ATRA) and arsenic trioxide in APLVenetoclax and obinutuzumab in CLL (the 12-month CLL14 regimen)

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References

2 references
Show all references, 1 with a study cardClose the reference list

Numbers in the text, such as [1], refer to these sources. Sources with a “Study card” button are summarised in the site’s evidence library.

  1. 1
    An international prognostic index for patients with chronic lymphocytic leukaemia (CLL-IPI): a meta-analysis of individual patient dataLancet Oncol · 2016;17:779-790
    DOIPubMed Back to text
  2. 2
    iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLLHallek M, Cheson BD, Catovsky D, et al · Blood · 2018;131:2745-2760
    Study cardDOIPubMed Back to text

This page is based on reputable scientific sources and was last updated on 27 October 2026. The content of this website is for educational and informational purposes only and does not replace consultation, diagnosis or treatment by a specialist physician. Consult your treating physician about any treatment decision.

Printed from the website; the full and up-to-date version: https://drdabiri.com/en/tools/cll-ipi-calculator/

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