Questions and answers

What is the difference between a benign and a malignant tumour?

Invasion, spread and recurrence, and why only a tissue sample can tell the type of tumour

Updated: 28 October 20261 min read6 references
Short answer

A benign tumour does not grow into nearby tissue or spread to other parts of the body, and it usually does not grow back after it is removed; a malignant tumour (cancer), however, can invade nearby tissue, and its cells can travel through the blood or lymph to distant organs and form new tumours (metastasis) [1]. "Benign" does not always mean harmless; some benign tumours, such as brain tumours, can cause serious symptoms or be life-threatening [1]. In most cases, only a biopsy and examination of the tissue under a microscope can tell the type of tumour with certainty [5].

Key points

  • Invasion of tissue and metastasis are fundamental features of cancer that set it apart from benign growths [2].
  • Between "normal" and "cancer" there are precancerous states such as dysplasia and carcinoma in situ; carcinoma in situ is not yet invasive cancer, but some may become cancer [1].

Benign and malignant tumours compared

FeatureBenign tumourMalignant tumour (cancer)
Growth into nearby tissueNo [1]Can invade nearby tissue [1]
Spread to distant sites (metastasis)No [1]Cells can travel through the blood or lymph to distant sites [1]
Regrowth after removalUsually does not grow back [1]Sometimes comes back [1]
Risk to healthUsually low, but can be serious depending on size and location (for example the brain) [1]Depends on type and stage; needs specialist treatment
Familiar examplesMost thyroid nodules [3]; bowel polyps (some are precancerous) [4]Breast, bowel, lung cancers and others

Only a doctor can determine the exact type of a tumour, by examining the tissue.

Diagram of uncontrolled cell division and tumour formation among normal cells
A tumour forms when cells divide without control. In a benign tumour the cells stay in place; in a malignant tumour (cancer) they can grow into nearby tissue and reach other parts of the body through the blood or lymph.Image: Cancer Research UK · CC BY-SA 4.0 · Wikimedia Commons (adapted: Persian labels)

How does the doctor find out the type of tumour?

  1. 1

    Examination and imaging

    Ultrasound, CT, MRI, nuclear scans and PET give a detailed picture of a lump, but they must be interpreted together with other methods [5].

  2. 2

    Laboratory tests

    They may be normal despite cancer and abnormal in healthy people; so on their own they do not make the diagnosis [5].

  3. 3

    Biopsy

    In most cases, doctors need a biopsy to be sure cancer is present; a pathologist examines the tissue under a microscope and records the result in a pathology report [5].

When should I call my doctor?

Show your doctor any new lump (in the breast, neck, testicle, armpit or anywhere else), a lump that is getting bigger, a change in a mole, a sore that does not heal, unusual bleeding and unexplained weight loss. Most lumps are benign, but a diagnosis is only possible with an examination and the right tests.

Related questions

Can a benign tumour become malignant?

Some benign or precancerous lesions can become cancerous over time; for example, most bowel cancers start from benign polyps, and removing polyps during screening prevents cancer [4].

My doctor says my lesion is "carcinoma in situ"; does that mean I have cancer?

Carcinoma in situ is sometimes called "stage zero", but the abnormal cells have not yet grown into the surrounding tissue; because some may become cancer, they are usually treated [1]. A familiar example in the breast is DCIS [6].

Does a biopsy make a tumour spread?

The risk is very low. Read more: Does a biopsy make cancer spread?

References

6 references
Show all references, 4 with a study cardClose the reference list

Numbers in the text, such as [1], refer to these sources. Sources with a “Study card” button are summarised in the site’s evidence library.

  1. 1
    What Is Cancer?National Cancer Institute · cancer.gov
    Source Back to text: 1 2 3 4 5 6 7 8 9 10 11
  2. 2
    Hallmarks of Cancer: New DimensionsHanahan D · Cancer Discovery · 2022;12:31-46
  3. 3
    ACR Thyroid Imaging, Reporting and Data System (TI-RADS): White Paper of the ACR TI-RADS CommitteeTessler FN, Middleton WD, Grant EG, Hoang JK, Berland LL, Teefey SA, et al · J Am Coll Radiol · 2017;14:587-595
  4. 4
    Colorectal cancerDekker E, Tanis PJ, Vleugels JLA, Kasi PM, Wallace MB · Lancet · 2019;394:1467-1480
    Study cardDOIPubMed Back to text: 1 2
  5. 5
    Tests and Procedures Used to Diagnose CancerNational Cancer Institute · cancer.gov
    Source Back to text: 1 2 3 4
  6. 6
    Breast cancerLoibl S, Poortmans P, Morrow M, Denkert C, Curigliano G · The Lancet · 2021;397:1750-1769

This page is based on reputable scientific sources and was last updated on 28 October 2026. The content of this website is for educational and informational purposes only and does not replace consultation, diagnosis or treatment by a specialist physician. Consult your treating physician about any treatment decision.