Drug

Ipilimumab (Yervoy)

CTLA-4 inhibitor immunotherapy, often combined with nivolumab

Updated: 27 October 20269 min read12 references
Generic name
Ipilimumab
Brand names
Yervoy
Drug class
Immune checkpoint inhibitor (anti-CTLA-4 antibody)
Route
Intravenous infusion
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Key points

  • Ipilimumab (Yervoy) is an immunotherapy drug that makes immune cells more active against cancer [1].
  • It is used for melanoma (alone or with nivolumab) and, only together with nivolumab, for kidney, bowel, liver, lung and oesophageal cancer [1].
  • It is given as a 30-minute drip, usually every 3 weeks for up to 4 doses [1].
  • The main risk is immune-related inflammation, especially of the bowel (diarrhoea), liver and glands; report any new symptom early [1] (immunotherapy side effects).
  • Liver, kidney, thyroid and hormone tests are done before starting and before each dose [1].
  • Women should avoid pregnancy during treatment and for 3 months after the last dose, and should not breastfeed [1].
For physicians

What is this drug and how does it work?

For physiciansIpilimumab
For physicians

Ipilimumab (brand name Yervoy) is a human IgG1 monoclonal antibody that blocks CTLA-4 [1]. It is an immune checkpoint inhibitor and, instead of attacking cancer cells directly, works by releasing the brake on the immune system [1].

CTLA-4 is a negative regulator of T-cell activity. Ipilimumab binds CTLA-4 and blocks its interaction with its ligands (CD80 and CD86) [1]. This increases the activation and proliferation of T cells, including tumour-infiltrating effector T cells, and may also reduce regulatory T-cell function; the result is an overall increase in T-cell responsiveness and the antitumour response [1].

CTLA-4 and PD-1 are two distinct immune inhibitory pathways; according to the nivolumab label, combined blockade with nivolumab (a PD-1 inhibitor) and ipilimumab enhances T-cell function more than either drug alone [2]. Except in melanoma, ipilimumab is approved only with nivolumab [1]. This immune enhancement is also the main reason for the drug's side effects [1].

Which cancers is it used for?

According to the FDA label, ipilimumab is approved in melanoma alone or with nivolumab, and in other cancers only with nivolumab (and in lung cancer sometimes with chemotherapy) [1]. In metastatic lung cancer and oesophageal cancer, PD-L1 expression, and in colorectal cancer, MSI-H/dMMR status, play a role in patient selection [1]. Approved uses may differ between countries, and not every patient is a candidate for this drug.

For patients
What is this drug for?

Your doctor may prescribe this drug for:

  • Melanoma [1, 3, 4, 5]
  • Kidney cancer (renal cell carcinoma) [1, 6]
  • MSI-H or dMMR colorectal cancer [1, 7]
  • Hepatocellular carcinoma [1, 8]
  • Non-small cell lung cancer [1, 9]
  • Malignant pleural mesothelioma [1, 10]
  • Oesophageal cancer (squamous cell carcinoma) [1, 11]

Whether it suits you depends on the type and stage of your cancer and your test results. Details of each use are in the section for doctors.

For physiciansApproved uses (FDA label) and key evidence
For physicians
Approved uses (FDA label) and key evidence
CancerConditions of useKey evidence
MelanomaUnresectable or metastatic melanoma, alone or with nivolumab, in adults and children aged 12 and over; adjuvant treatment (alone) in adults with cutaneous melanoma with regional lymph node involvement of more than 1 mm after complete resection and complete lymphadenectomy [1]MDX010-20 [3]; E1609 [4]; CheckMate 067 [5]
Kidney cancer (renal cell carcinoma)First line for intermediate-‎ or poor-risk advanced disease, with nivolumab [1]CheckMate 214 trial [6]
MSI-H or dMMR colorectal cancerUnresectable or metastatic disease, with nivolumab, in adults and children aged 12 and over [1]CheckMate 8HW trial [7]
Hepatocellular carcinomaUnresectable or metastatic disease with nivolumab, first line or after prior sorafenib [1]CheckMate 9DW trial [8]
Non-small cell lung cancerFirst line for metastatic disease with PD-L1 ≥1% and no EGFR or ALK alterations, with nivolumab; or first line for metastatic or recurrent disease without EGFR or ALK alterations, with nivolumab and 2 cycles of platinum doublet chemotherapy [1]CheckMate 227 trial [9]
Malignant pleural mesotheliomaFirst line for unresectable disease, with nivolumab [1]CheckMate 743 trial [10]
Oesophageal cancer (squamous cell carcinoma)First line for advanced unresectable or metastatic disease with PD-L1 ≥1, with nivolumab [1]CheckMate 648 trial [11]

A summary of the FDA label; the full label has the details of each use. Neoadjuvant ipilimumab and nivolumab in resectable stage III melanoma was studied in the NADINA trial [12], but this use is not among the approved indications in the current FDA label [1].

How it is taken and dosing

Show detailsHide
Treatment regimens and doses: index10 regimens

Ipilimumab is given at a treatment centre as an intravenous drip over about 30 minutes [1]. When it is given with nivolumab, nivolumab is given first on the same day and then ipilimumab; if chemotherapy is also part of the treatment, it is given after these two [1].

Treatment schedule: in advanced melanoma (alone or with nivolumab) and in kidney, bowel and liver cancer, ipilimumab is usually given every 3 weeks for up to 4 doses, after which nivolumab continues on its own [1]. In lung cancer, mesothelioma and oesophageal cancer, ipilimumab is given every 6 weeks with nivolumab for up to 2 years [1]. In adjuvant treatment of melanoma, 4 doses are given every 3 weeks and then every 12 weeks for up to 4 more doses [1].

Tests: liver enzymes, creatinine, ACTH and thyroid function are checked before starting and before each dose [1]. If you miss an appointment, contact your treatment team as soon as possible to arrange a new one [1].

For physicians
Prescribing notes: patient selection, administration, dose modification and monitoring
  • Patient selection: PD-L1 in NSCLC and ESCC, and MSI-H/dMMR in colorectal cancer [1].
  • Administration: dilute in 0.9% saline or 5% dextrose (1 to 2 mg/mL), infuse over 30 minutes with a low protein-binding in-line filter, through a separate line, and flush the line after each dose [1]. Premedication is not routinely given in the label; grade 1 to 2 infusion reaction: interrupt or slow the rate; grade 3 to 4: discontinue permanently [1].
  • Dose modification: no dose reductions are recommended; with nivolumab, both drugs are withheld or discontinued together. Discontinue permanently: grade 4 immune-related adverse reaction; recurrent grade 3 requiring immunosuppression; grade 2 or 3 persisting 12 weeks or more after the last dose (except endocrine); inability to taper prednisone to 10 mg/day within 12 weeks. Grade 2 colitis: withhold; grade 3 to 4: discontinue permanently. Hepatitis without liver involvement (or non-HCC): ALT/AST above 3 to 5 times ULN or bilirubin above 1.5 to 3 times: withhold; ALT/AST above 5 times or bilirubin above 3 times: discontinue permanently. Grade 2 pneumonitis: withhold; grade 3 to 4: discontinue. Nephritis (grade 2 to 3 creatinine): withhold; grade 4: discontinue. Grade 2 neurological toxicity: withhold; grade 3 to 4: discontinue. Grade 2 to 4 myocarditis: discontinue permanently. Grade 2 to 4 ocular adverse reaction not improving to grade 1 within 2 weeks of topical treatment or requiring systemic treatment: discontinue permanently [1].
  • Kidney and liver: renal impairment (GFR 15 mL/min/1.73 m² or more) and mild hepatic impairment have no important effect on clearance; the label gives no dose adjustment [1].
  • Monitoring: liver tests, creatinine, ACTH and thyroid function before starting and before each dose; symptoms of colitis (diarrhoea, blood in the stool), hypophysitis and adrenal insufficiency, pneumonitis and severe rash. Immune-related adverse reactions can occur after treatment ends [1].
For physiciansStandard dosing in melanoma (FDA label, revised 08/2026), 3 regimens · Other cancers, with nivolumab (FDA label, revised 08/2026), 7 regimens
For physicians

Standard dosing in melanoma (FDA label, revised 08/2026)

Unresectable or metastatic melanoma, monotherapy

Adults and children aged 12 and overCycle length: 21 days

Unresectable or metastatic melanoma, with nivolumab

Adults and children aged 12 and over

Adults and children aged 12 and over [1]

Before prescribing: Prescribing notes: patient selection, administration, dose modification and monitoring
DrugDoseRouteSchedule
Combination: 4 doses
Nivolumab1 mg/kgIV, 30-minute infusionDay 1 every 3 weeks (given first)
Ipilimumab3 mg/kgIV, 30-minute infusionSame day, straight after nivolumab
Maintenance
Nivolumab240 mg every 2 weeks or 480 mg every 4 weeksIV, 30-minute infusionStarting after the 4 combination doses
Cycle length
21 days, then 14 or 28 days
Duration
Combination up to 4 doses; nivolumab until progression or unacceptable toxicity [1, 2]

Children under 40 kg in the maintenance phase: nivolumab 3 mg/kg every 2 weeks or 6 mg/kg every 4 weeks [2].

Melanoma, adjuvant (monotherapy)

Cutaneous melanoma with regional node involvement of more than 1 mm after complete resection and complete lymphadenectomy

Doses follow the trial protocol, guideline or official drug label (source given in the notes of each regimen). Before prescribing, check blood counts, renal and hepatic function, drug interactions and the patient’s condition, and adjust the dose according to the drug label.

For physicians

Other cancers, with nivolumab (FDA label, revised 08/2026)

Advanced intermediate- or poor-risk renal cell carcinoma (CheckMate 214)

First line

First line [1]

Before prescribing: Prescribing notes: patient selection, administration, dose modification and monitoring
DrugDoseRouteSchedule
Combination: 4 doses
Nivolumab3 mg/kgIV, 30-minute infusionDay 1 every 3 weeks (given first)
Ipilimumab1 mg/kgIV, 30-minute infusionSame day, after nivolumab
Maintenance
Nivolumab240 mg every 2 weeks or 480 mg every 4 weeksIV, 30-minute infusionAfter the 4 combination doses
Cycle length
21 days, then 14 or 28 days
Duration
Combination 4 doses; nivolumab until progression or unacceptable toxicity [1, 2]

Evidence: CheckMate 214 (2026), CheckMate 214 (2018)

Unresectable or metastatic MSI-H/dMMR colorectal cancer (CheckMate 8HW)

Adults and children aged 12 and over; MSI-H/dMMR by an approved test

Adults and children aged 12 and over; MSI-H/dMMR by an approved test [1]

Before prescribing: Prescribing notes: patient selection, administration, dose modification and monitoring
DrugDoseRouteSchedule
Combination: up to 4 doses
Nivolumab240 mg (below 40 kg: 3 mg/kg)IV, 30-minute infusionDay 1 every 3 weeks (given first)
Ipilimumab1 mg/kgIV, 30-minute infusionSame day, after nivolumab
Maintenance
Nivolumab240 mg every 2 weeks or 480 mg every 4 weeks (below 40 kg: 3 mg/kg every 2 weeks or 6 mg/kg every 4 weeks)IV, 30-minute infusionAfter the combination doses
Cycle length
21 days, then 14 or 28 days
Duration
Nivolumab until progression, unacceptable toxicity or a maximum of 2 years [1, 2]

Evidence: CheckMate 8HW (2025), CheckMate 8HW (2024)

Unresectable or metastatic hepatocellular carcinoma (CheckMate 9DW)

First line or after sorafenib

First line or after sorafenib [1]

Before prescribing: Prescribing notes: patient selection, administration, dose modification and monitoring
DrugDoseRouteSchedule
Combination: up to 4 doses
Nivolumab1 mg/kgIV, 30-minute infusionDay 1 every 3 weeks (given first)
Ipilimumab3 mg/kgIV, 30-minute infusionSame day, straight after nivolumab
Maintenance
Nivolumab240 mg every 2 weeks or 480 mg every 4 weeksIV, 30-minute infusionAfter the combination doses
Cycle length
21 days, then 14 or 28 days
Duration
Nivolumab until progression, unacceptable toxicity or a maximum of 2 years [1, 2]

Evidence: CheckMate 9DW (2025)

Metastatic NSCLC with PD-L1 1% or more (CheckMate 227)

First line, without EGFR or ALK alterationsEach drug’s schedule in the table

Metastatic or recurrent NSCLC, with 2 cycles of chemotherapy (CheckMate 9LA)

First line, without EGFR or ALK alterationsEach drug’s schedule in the table

First line, without EGFR or ALK alterations [1]

Before prescribing: Prescribing notes: patient selection, administration, dose modification and monitoring
DrugDoseRouteSchedule
Continuous
Nivolumab360 mgIV, 30-minute infusionEvery 3 weeks
Ipilimumab1 mg/kgIV, 30-minute infusionEvery 6 weeks
First 2 cycles
Histology-based platinum doublet chemotherapyAs per those drugs' labelsIVEvery 3 weeks, after nivolumab and ipilimumab
Cycle schedule
Nivolumab every 3 weeks; ipilimumab every 6 weeks; chemotherapy every 3 weeks (2 cycles)
Duration
Immunotherapy until progression, unacceptable toxicity or a maximum of 2 years; chemotherapy 2 cycles [1]

Unresectable malignant pleural mesothelioma (CheckMate 743)

First lineEach drug’s schedule in the table

Oesophageal squamous cell carcinoma with PD-L1 1 or more (CheckMate 648)

First line, advanced unresectable or metastatic

First line, advanced unresectable or metastatic [1]

Before prescribing: Prescribing notes: patient selection, administration, dose modification and monitoring
DrugDoseRouteSchedule
Continuous
Nivolumab3 mg/kg every 2 weeks or 360 mg every 3 weeksIV, 30-minute infusionDay 1
Ipilimumab1 mg/kgIV, 30-minute infusionEvery 6 weeks
Cycle length
14 or 21 days (ipilimumab every 42 days)
Duration
Until progression, unacceptable toxicity or a maximum of 2 years [1]

Evidence: CheckMate 648 (2026), CheckMate 648 (2022)

Before prescribing, check each dose against the drug label, laboratory tests and the patient’s condition.

Side effects

For patients

The most common side effects:

  • Tiredness, diarrhoea, itching and skin rash, nausea and headache [1].
  • Side effects are more common when it is given with nivolumab: muscle and joint pain, fever, cough, poor appetite, abdominal pain and an underactive thyroid [1].
  • Report any new or worsening symptom early; it may be the first sign of an immune side effect [1].
For physiciansalone · Frequency of some adverse reactions to ipilimumab (all grades)
For physicians

According to the FDA label, the most common adverse reactions to ipilimumab alone (20% or more) are fatigue, diarrhoea, pruritus, rash, nausea and headache [1]. In combination with nivolumab, the list of common adverse reactions is longer and also includes musculoskeletal pain, pyrexia, cough, decreased appetite, vomiting, abdominal pain, dyspnoea, upper respiratory tract infection, arthralgia, hypothyroidism, constipation, weight loss and dizziness [1].

The table below shows the frequency of some adverse reactions in three trials: MDX010-20 (advanced melanoma, ipilimumab 3 mg/kg alone, 131 patients), E1609 (adjuvant melanoma, ipilimumab 3 mg/kg, 516 patients) and CheckMate 067 (advanced melanoma, ipilimumab with nivolumab, 313 patients) [1].

For physicians
Frequency of some adverse reactions to ipilimumab (all grades)
Adverse reactionMonotherapy, advanced melanoma (MDX010-20)Adjuvant melanoma (E1609)With nivolumab (CheckMate 067)
Fatigue41% [1]56% [1]62% [1]
Diarrhoea32% [1]49% [1]54% [1]
Pruritus31% [1]41% [1]—
Rash29% [1]46% [1]53% [1]
Colitis8% [1]10% [1]—
Nausea—29% [1]44% [1]
Headache—25% [1]—
Pyrexia—10% [1]40% [1]

“—” means the reaction was not reported in that trial's table in the FDA label. Figures from different trials are not directly comparable.

Serious side effects

For patients

Ipilimumab, more than most immunotherapy drugs, can make the immune system attack healthy organs; these side effects can happen at any time, even after treatment has ended [1] (immunotherapy side effects):

  • Bowel: diarrhoea, abdominal pain or blood in the stool; the most common serious side effect of this drug [1].
  • Skin: a widespread rash, blisters or mouth sores [1].
  • Liver: yellow skin or eyes, dark urine [1].
  • Glands (thyroid, pituitary, adrenal): severe tiredness, headache, dizziness, changes in weight or mood [1].
  • Lungs, kidneys, nerves, heart and eyes: cough or shortness of breath, passing less urine, weakness or numbness, palpitations, blurred vision or eye pain [1].
  • Harm to an unborn baby [1].
For physiciansimmune-related adverse reactions
For physicians

Ipilimumab can cause severe or fatal immune-related adverse reactions in any organ; they may appear at any time after starting treatment and even after it is stopped [1]. Frequencies depend on the dose and combination [1]:

  • Ipilimumab 3 mg/kg alone (511 patients): colitis 12% (grade 3 to 5: 7%), immune-mediated rash 15%, immune-mediated hepatitis 4.1%, and grade 2 to 5 endocrinopathies in 4% [1].
  • Ipilimumab 3 mg/kg with nivolumab 1 mg/kg (melanoma or HCC, 456 patients): colitis 25%, immune-mediated rash 28%, hypothyroidism 20%, hepatitis 15%, hypophysitis 9%, hyperthyroidism 9%, adrenal insufficiency 8% and pneumonitis 7% [1].
  • Ipilimumab 1 mg/kg with nivolumab 3 mg/kg (RCC or CRC, 666 patients): hypothyroidism 18%, immune-mediated rash 16%, hyperthyroidism 12%, colitis 9%, hepatitis 7%, adrenal insufficiency 7%, hypophysitis 4.4%, nephritis 4.1%, pneumonitis 3.9% and diabetes 2.7% [1].
  • Rarer reactions: autoimmune neuropathy (2%), pancreatitis (1.3%), meningitis, encephalitis, myasthenia gravis, Guillain-Barré syndrome, myocarditis and ocular inflammation such as uveitis [1].
  • Infusion-related reactions: 0.6% with ipilimumab 3 mg/kg alone and 5% with ipilimumab 1 mg/kg with nivolumab [1].

In the adjuvant trial E1609, fatal adverse reactions occurred in 1.4% of patients receiving ipilimumab and 35% permanently stopped the drug because of an adverse reaction [1]. Severe or fatal graft-versus-host disease may occur in patients given ipilimumab before or after allogeneic stem cell transplantation [1]. Ipilimumab can harm a fetus, with effects probably greater in the second and third trimesters [1]. The current FDA label for this drug has no boxed warning [1].

When should I call my doctor?

If you have any of these new or worsening symptoms, contact your doctor or treatment team straight away, even if treatment has finished [1]:

  • Diarrhoea or more frequent bowel movements, black tarry stools or stools with blood or mucus, or severe abdominal pain or tenderness [1]
  • Yellow skin or whites of the eyes, severe nausea or vomiting, pain on the right side of the abdomen, dark (tea-coloured) urine, or bleeding and bruising easily [1]
  • Rash, itching, blistering or peeling skin, or painful sores in the mouth, nose, throat or genital area [1]
  • A persistent or unusual headache, eye sensitivity to light, palpitations, heavy sweating, extreme tiredness, weight change, excessive thirst or hunger, passing a lot of urine, dizziness or fainting [1]
  • A new or worsening cough, shortness of breath or chest pain [1]
  • Passing less urine, blood in the urine or swollen ankles [1]
  • Blurred or double vision or other eyesight problems, eye pain or redness [1]
  • During the infusion: chills, itching or rash, flushing, shortness of breath or wheezing, dizziness, feeling faint, fever, or back or neck pain [1]

In severe cases (such as severe shortness of breath, severe bloody diarrhoea or reduced consciousness), call your local emergency number.

Interactions, pregnancy and precautions

Drug interactions: the FDA label for ipilimumab has no section on drug interactions [1]; even so, tell your doctor about all your medicines, over-the-counter drugs, vitamins and herbal supplements [1]. The safety and effectiveness of ipilimumab with vemurafenib have not been established, and in a dose-finding study grade 3 liver enzyme rises occurred in 6 of 10 patients [1].

Before starting treatment, tell your doctor if you have an autoimmune disease (such as ulcerative colitis, Crohn disease or lupus), have had an organ transplant or a stem cell transplant from a donor, or have a nerve disease such as myasthenia gravis or Guillain-Barré syndrome [1].

Pregnancy and contraception: ipilimumab may harm an unborn baby. Pregnancy status is checked before starting, and women who could become pregnant should use effective contraception during treatment and for 3 months after the last dose [1].

Breastfeeding: do not breastfeed during treatment and for 3 months after the last dose [1].

Fertility: no studies have looked at the effect of ipilimumab on fertility [1]; if you are planning a family, talk to your doctor before starting treatment.

Vaccines: the FDA label gives no specific advice about vaccination [1]; talk to your treatment team before any vaccine.

Frequently asked questions

Is ipilimumab chemotherapy?

No. Ipilimumab is an immunotherapy from the immune checkpoint inhibitor group that works with the body's immune system [1].

Why is ipilimumab usually given with nivolumab?

Ipilimumab blocks the CTLA-4 pathway and nivolumab the PD-1 pathway, and blocking both at once boosts T-cell function more than either drug alone [2]. Except in melanoma, ipilimumab is approved only with nivolumab [1].

How long does treatment last?

In most regimens ipilimumab is given for up to 4 doses (every 3 weeks), after which nivolumab continues on its own; in lung cancer, mesothelioma and oesophageal cancer for up to 2 years, and in adjuvant treatment of melanoma for up to 4 more doses every 12 weeks [1].

Is diarrhoea during treatment serious?

Diarrhoea is a common side effect, but it may be a sign of immune colitis, which can be fatal [1]. Report any new diarrhoea, more frequent bowel movements, bloody stools or severe abdominal pain to your doctor straight away [1].

Can side effects start after treatment has ended?

Yes. Immune-related side effects usually appear during treatment, but they can also appear after the drug is stopped [1].

Key studies

Show detailsHide

Key studies

6 items
Clinical trial · Phase 3

Final, 10-Year Outcomes with Nivolumab plus Ipilimumab in Advanced Melanoma

N Engl J Med · 2025
71.9 / 36.9 / 19.9 monthsMedian overall survival
Clinical trial · Phase 3

Nivolumab plus Ipilimumab in Microsatellite-Instability-High Metastatic Colorectal Cancer

N Engl J Med · 2024
72% vs 14%24-month progression-free survival (first line)
Clinical trial · Phase 3

Nivolumab plus ipilimumab versus lenvatinib or sorafenib as first-line treatment for unresectable hepatocellular carcinoma (CheckMate 9DW): an open-label, randomised, phase 3 trial

Lancet · 2025
23.7 vs 20.6 monthsMedian overall survival
Clinical trial · Phase 3

Neoadjuvant Nivolumab and Ipilimumab in Resectable Stage III Melanoma

N Engl J Med · 2024
83.7% vs 57.2%12-month event-free survival
Clinical trial · Phase 3

Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma

N Engl J Med · 2018
75% vs 60%18-month overall survival (intermediate/poor risk)
Clinical trial · Phase 3

Nivolumab Combination Therapy in Advanced Esophageal Squamous-Cell Carcinoma

N Engl J Med · 2022
15.4 vs 9.1 monthsMedian overall survival, nivolumab + chemotherapy (PD-L1 ≥1%)

References

12 references
Show all references, 10 with a study cardClose the reference list

Numbers in the text, such as [1], refer to these sources. Sources with a “Study card” button are summarised in the site’s evidence library.

  1. 1
    YERVOY (ipilimumab) injection, for intravenous use: Prescribing InformationBristol-Myers Squibb Company · DailyMed, U.S. National Library of Medicine · 2026
  2. 2
    OPDIVO (nivolumab) injection, for intravenous use: Prescribing InformationBristol-Myers Squibb Company · DailyMed, U.S. National Library of Medicine · 2026
    Source Back to text: 1 2 3 4 5 6 7
  3. 3
    Improved Survival with Ipilimumab in Patients with Metastatic MelanomaHodi FS, O'Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, et al · N Engl J Med · 2010;363:711-723
    Study cardDOIPubMed Back to text: 1 2
  4. 4
    Phase III Study of Adjuvant Ipilimumab (3 or 10 mg/kg) Versus High-Dose Interferon Alfa-2b for Resected High-Risk Melanoma: North American Intergroup E1609Tarhini AA, Lee SJ, Hodi FS, Rao UNM, Cohen GI, Hamid O, et al · J Clin Oncol · 2020;38:567-575
    Study cardDOIPubMed Back to text: 1 2
  5. 5
    Final, 10-Year Outcomes with Nivolumab plus Ipilimumab in Advanced MelanomaWolchok JD, Chiarion-Sileni V, Rutkowski P, Cowey CL, Schadendorf D, Wagstaff J, et al · N Engl J Med · 2025;392:11-22
    Study cardDOIPubMed Back to text: 1 2
  6. 6
    Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell CarcinomaMotzer RJ, Tannir NM, McDermott DF, Arén Frontera O, Melichar B, Choueiri TK, et al · N Engl J Med · 2018;378:1277-1290
    Study cardDOIPubMed Back to text: 1 2
  7. 7
    Nivolumab plus Ipilimumab in Microsatellite-Instability-High Metastatic Colorectal CancerAndré T, Elez E, Van Cutsem E, et al · N Engl J Med · 2024;391:2014-2026
    Study cardDOIPubMed Back to text: 1 2
  8. 8
    Nivolumab plus ipilimumab versus lenvatinib or sorafenib as first-line treatment for unresectable hepatocellular carcinoma (CheckMate 9DW): an open-label, randomised, phase 3 trialYau T, Galle PR, Decaens T, et al · Lancet · 2025;405:1851-1864
    Study cardDOIPubMed Back to text: 1 2
  9. 9
    Nivolumab plus Ipilimumab in Advanced Non–Small-Cell Lung CancerHellmann MD, Paz-Ares L, Bernabe Caro R, Zurawski B, Kim SW, Carcereny Costa E, et al · N Engl J Med · 2019;381:2020-2031
    Study cardDOIPubMed Back to text: 1 2
  10. 10
    First-line nivolumab plus ipilimumab in unresectable malignant pleural mesothelioma (CheckMate 743): a multicentre, randomised, open-label, phase 3 trialBaas P, Scherpereel A, Nowak AK, Fujimoto N, Peters S, Tsao AS, et al · Lancet · 2021;397:375-386
    Study cardDOIPubMed Back to text: 1 2
  11. 11
    Nivolumab Combination Therapy in Advanced Esophageal Squamous-Cell CarcinomaDoki Y, Ajani JA, Kato K, et al · N Engl J Med · 2022;386:449-462
    Study cardDOIPubMed Back to text: 1 2
  12. 12
    Neoadjuvant Nivolumab and Ipilimumab in Resectable Stage III MelanomaBlank CU, Lucas MW, Scolyer RA, van de Wiel BA, Menzies AM, Lopez-Yurda M, et al · N Engl J Med · 2024;391:1696-1708

This page is based on reputable scientific sources and was last updated on 27 October 2026. The content of this website is for educational and informational purposes only and does not replace consultation, diagnosis or treatment by a specialist physician. Consult your treating physician about any treatment decision.